Cancer Weekly
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Cancer Gene Therapy
Reports outline cancer gene therapy study results from Dankook University
March 25th, 2008
"We have developed and validated a new tumor-targeting gene therapy strategy based upon the targeting and replacement of human telomerase reverse transcriptase (hTERT) RNA, using a trans-splicing ribozyme. By constructing novel adenoviral vectors harboring the hTERT-targeting trans-splicing ribozymes with the downstream reporter gene (Ad- Ribo-LacZ) or suicide gene (Ad-Ribo-HSVtk) driven by the cytomegalovirus (CMV) promoter, we demonstrated that this viral system selectively marks tumor cells expressing hTERT or sensitizes tumor cells to prodrug treatments," scientists in Seoul, South Korea report. "We confirmed that Ad- Ribo-LacZ successfully and selectively delivered...
Source: Cancer Weekly (2008-03-25)
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