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Cancer Gene Therapy
Study findings from University of Hong Kong, Medical Department broaden understanding of cancer gene therapy
March 25th, 2008
According to a study from Hong Kong, People's Republic of China, "Angiogenesis inhibitors have strong therapeutic potential as antitumor agents in suppressing tumor growth and metastatic progression. Vasostatin, the N-terminal domain of calreticulin, is a potent angiogenesis inhibitor." "In this study, we determined the effectiveness of vasostatin delivered by recombinant pseudotype adeno-associated virus 2/5 (rAAV2/5-VAS) as a gene therapy approach for lung cancer treatment. We used rAAV2/5 to deliver vasostatin intratumorally or systemically in different mouse lung tumor models-subcutaneous, orthotopic xenograft, and spontaneous metastasis lung tumor models. The...
Source: Cancer Weekly (2008-03-25)
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