Cancer Weekly
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Cancer Vaccines
New findings from N.H. Segal and co-researchers in the area of cancer vaccines described
April 1st, 2008
"The finding that individual cancers contain many mutant genes not present in normal tissues has prompted considerable interest in the cancer epitope landscape," scientists writing in the journal Cancer Research report. "To further understand such effects, we applied in silico-based epitope prediction algorithms and high throughput post hoc analysis to identify candidate tumor antigens. Analysis of 1,152 peptides containing missense mutations previously identified in breast and colorectal cancer revealed that individual cancers accumulate on average similar to 10 and similar to 7 novel and unique HLA-A*0201 epitopes, respectively, including genes implicated in...
Source: Cancer Weekly (2008-04-01)
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