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Apoptosis Gene Therapy
Researchers from Chiba Cancer Center Research Institute, Division of Biochemistry provide details of new studies and findings in the area of apoptosis gene therapy
April 1st, 2008
A report, 'Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress,' is newly published data in Journal of Biological Chemistry. "Tumor suppressor p53-dependent stress response pathways play an important role in cell fate determination. In this study, we have found that glucose depletion promotes the phosphorylation of AMP-activated protein kinase catalytic subunit alpha (AMPKalpha) in association with a significant up-regulation of p53, thereby inducing p53-dependent apoptosis in vivo and in vitro," scientists in Chiba, Japan report. "Thymocytes prepared from glucose-depleted wild-type mice but not...
Source: Cancer Weekly (2008-04-01)
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