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Cancer Gene Therapy
New research on cancer gene therapy from University of Massachusetts, Cancer Center summarized
April 1st, 2008
Scientists discuss in 'Hsp60 regulation of tumor cell apoptosis' new findings in cancer gene therapy. According to recent research published in the Journal of Biological Chemistry, "Molecular chaperones may promote cell survival, but how this process is regulated, especially in cancer, is not well understood. Using high throughput proteomics screening, we identified the cell cycle regulator and apoptosis inhibitor survivin as a novel protein associated with the molecular chaperone Hsp60." "Acute ablation of Hsp60 by small interfering RNA destabilizes the mitochondrial pool of survivin, induces mitochondrial dysfunction, and activates caspase-dependent apoptosis....
Source: Cancer Weekly (2008-04-01)
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