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Cancer Gene Therapy
Researchers from Hashemite University discuss findings in cancer gene therapy
April 1st, 2008
New investigation results, '2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress,' are detailed in a study published in Free Radical Biology & Medicine. "Overexpression of the tumor suppressor gene, wild-type p53 (wtp53), using adenoviral vectors (Adp53) has been suggested to kill cancer cells by hydroperoxide-mediated oxidative stress [1,2] and nutrient distress induced by the glucose analog, 2-deoxyglucose (2DG), has been suggested to enhance tumor cell killing by agents that induce oxidative stress via disrupting hydroperoxide metabolism [3,4]. In the current study clonogenic cell killing of PC-3 and...
Source: Cancer Weekly (2008-04-01)
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