Cancer Weekly
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RNA Research
Study data from F. Battaglia and colleagues update understanding of RNA research
April 1st, 2008
Current study results from the report, 'Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB,' have been published. "Hypoxia, a condition of low oxygen tension, occurring in many pathological processes, modifies the mononuclear phagocyte transcriptional profile. Here, we demonstrate hypoxic up-regulation of the CCL20 chemokine in primary human monocytes (Mn) and macrophages. mRNA induction was paralleled by protein secretion and dependent on gene transcription activation," scientists in Italy report. "Functional studies of the CCL20 promoter using a series of 5'-deleted...
Source: Cancer Weekly (2008-04-01)
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