Adverse Drug Reactions

Studies from Medical University of Graz yield new data on adverse drug reactions

Published in Cancer Weekly, April 1st, 2008

"Hemophagocytic lymphohistiocytosis (HLH) during childhood cancer treatment is a rare adverse event posing major diagnostic and therapeutic challenges. Between 1995 and 2006, 6 children developed HLH while on conventional chemotherapy (n=4) or after allogeneic stem cell transplantation (n=2)," scientists in Graz, Austria report.

"Treatment of HLH included dexamethasone and etoposide, 2 children additionally received infliximab or daclizumab. Three children survived, whereas 3 children died 2, 5, and 47 days after diagnosis of HLH. HLH is a severe adverse event of childhood cancer therapy," wrote H. Lackner and colleagues, Medical University of Graz.

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Source: Cancer Weekly (2008-04-01)

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