Cancer Weekly
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Angiomatosis
Research from University of Leuven in the area of angiomatosis published
April 1st, 2008
According to a study from Louvain, Belgium, "The developmentally regulated PLAG1 protooncogene has been implicated in the development of various human tumor types, such as pleomorphic salivary gland adenomas, lipoblastomas, hepatoblastomas and AML. In previous studies, we generated two independent PIAG1 transgenic founder strains, PTMS I and PTMS2, in which PLAG1 could be activated via Cre-mediated excision of a stop cassette." "With these founders, PLAG1-induced tumor formation in salivary and mammary glands of mice was studied. To further delineate the oncogenic spectrum of PLAG1 in mice, we induced aP2-Cre-mediated overexpression of PLAG1 in offspring from...
Source: Cancer Weekly (2008-04-01)
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