Cancer Weekly
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Apoptosis
Research from Tor Vergata University in apoptosis provides new insights
April 1st, 2008
"The objective of this study was to gain insight into the molecular mechanism of induced cell death (apoptosis) by PYRROLO [1,2-b][1,2,5] BENZOTHIADIAZEPINES (PBTDs) series compounds, using human (K562) cells as a model. We focused our attention on some members of the PBTDs family to test their potential apoptotic activity in K562 cells," scientists in Rome, Italy report. "Important apoptotic activity was demonstrated, as evidenced by the concentration and percentage of cell death quantified by measuring PI-uptake by flow cytometry, and DNA fragmentation analyzed by agarose gel electrophoresis, generating a characteristic ladder pattern of discontinuous DNA fragments....
Source: Cancer Weekly (2008-04-01)
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