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Cancer Weekly

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Bioengineering



Data on bioengineering published by researchers at Australian National University



April 1st, 2008

According to a study from Canberra, Australia, "Objectives and methods The aim of this study was to investigate genetic variation in glutathione transferase omega 1 (GST01-1) in Atacamenos, an indigenous population from Chile that has been exposed to environmental arsenic for many generations. GST01-1 is thought to catalyse the rate-limiting step in the biotransformation of arsenic in humans and may modulate the response of cancer patients to arsenic trioxide therapy."

"Allele frequencies were determined by PCR-based methods and a polymorphic variant (GST01-1 VaI236) was expressed in Escherichia coli and functionally characterized. Urinary arsenic profiles were...


Source: Cancer Weekly (2008-04-01)

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