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Cancer Gene Therapy
Research from M. Lakatosovaandelova and colleagues provide new insights into cancer gene therapy
April 1st, 2008
According to recent research from Prague, Czech Republic, "One of the gene therapy strategies in oncology is immunization with cancer cells that express various cytokines. We used a thymidine-kinase deficient (cTK(-)) cell line designated 123IA, which had been derived from HPV16-transformed mouse (C57BL/6) cells MK16/I/III/ABC (MK16)." "To obtain genetically modified cells, 123IA cells were transfected with bicistronic plasmid vectors carrying the herpes simplex type I thymidine kinase (HSV TK) gene and either the gene for the mouse B7.1 (CD80) co-stimulatory molecule or the gene for the monocyte-chemoattractant protein 1 (MCP-1). For control purposes, a plasmid vector...
Source: Cancer Weekly (2008-04-01)
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