Cancer Weekly
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Cancer Vaccines
Studies from A.N.H. Khan and colleagues provide new data on cancer vaccines
April 8th, 2008
"Numerous immune genes are epigenetically silenced in tumor cells and agents such as histone deacetylase inhibitors (HDACi), which reverse these effects, could potentially be used to develop therapeutic vaccines. The conversion of cancer cells to antigen presenting cells (APCs) by HDACi treatment could potentially provide an additional pathway, together with cross-presentation of tumor antigens by host APCs, to establish tumor immunity," scientists in the United States report. "HDACi-treated B16 melanoma cells were used in a murine vaccine model, lymphocyte subset depletion, ELISpot and Cytotoxicity assays were employed to evaluate immunity. Antigen presentation assays,...
Source: Cancer Weekly (2008-04-08)
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