Cancer Weekly
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Melanoma
Studies in the area of melanoma reported from University of Buenos Aires
April 8th, 2008
"Canine spontaneous melanoma is a highly aggressive tumor resistant to current therapies. We evaluated the safety, efficacy and antitumor effects of direct intratumor injections of lipoplexes encoding herpes simplex thymidine kinase coadministrated with ganciclovir, and irradiated transgenic xenogeneic cells secreting 20-30 mg day(-1) of human granulocyte-macrophage colony-stimulating factor and interleukin-2," researchers in Buenos Aires, Argentina report. "Toxicity was minimal or absent in all patients. This combined treatment (CT) induced tumor regression and a pronounced immune cell infiltration. The objective responses (47%: 21/45) averaged 80% of tumor mass loss....
Source: Cancer Weekly (2008-04-08)
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