Neuroblastoma
Researchers from Seoul National University, Medical Department report on findings in neuroblastoma
Published in Cancer Weekly, April 8th, 2008
"Heterotrimeric stimulatory GTP-binding protein (Gs) stimulates adenylate cyclases to activate the cAMP signaling pathway. Although the cAMP pathway has been reported to be involved in apoptosis, the role of the G(s)-cAMP signaling pathway during reactive oxygen species (ROS)-mediated apoptosis, which is involved in the resistance of cancer cells to chemotherapy and radiation, is not clearly understood," investigators in Seoul, South Korea report.
"Thus, in this study we aimed to investigate the role of the alpha subunit of G(s) (G alpha(s)) in the ROS-induced apoptosis of cancer cells. The stable expression of constitutively active G alpha(s)(G alpha(s)QL) inhibited...
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Source: Cancer Weekly (2008-04-08)
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