Acute Myeloid Leukemia Therapy
Studies from Sun Yat-Sen University, Cancer Center in the area of acute myeloid leukemia therapy published
Published in Cancer Weekly, April 8th, 2008
Researchers detail in 'Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia,' new data in acute myeloid leukemia. "Previously, we and others showed that mitotic Aurora-A kinase (Aur-A) was required for accurate mitotic entry and proper spindle assembly. In this study, we found that expression of Aur-A was markedly elevated in bone marrow mononuclear cells (BMMCs) obtained from a significant portion of de novo acute myeloid leukemia (AML) patients," scientists in Guangzhou, People's Republic of China report.
"Targeting human primary AML cells with Aur-A kinase inhibitory VX-680 led to apoptotic cell death...
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Source: Cancer Weekly (2008-04-08)
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