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Immunization
Research reports from University Hospital, Department of Dermatology provide new insights into immunization
April 8th, 2008
Current study results from the report, 'Introduction of functional chimeric E/L-selectin by RNA electroporation to target dendritic cells from blood to lymph nodes,' have been published. According to recent research published in the journal Cancer Immunology, Immunotherapy, "Inefficient migration of dendritic cells (DC) to regional lymph nodes (LN) upon intracutaneous injection is a major obstacle for effective DC vaccination. Intravenous vaccination is unfavorable, because DC cannot migrate directly from the blood into LN." "To enable human monocyte-derived (mo)DC to enter LN directly from the blood, we manipulated them by RNA electroporation to express a human...
Source: Cancer Weekly (2008-04-08)
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