Cancer Weekly
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Acute Lymphoblastic Leukemia
Recent findings from V.D. Moore and co-authors highlight research in acute lymphoblastic leukemia
April 8th, 2008
According to recent research from the United States, "Cancer cells acquire disruptions in normal signal transduction pathways and homeostatic mechanisms that would trigger apoptosis in normal cells. These abnormalities include genomic instability, oncogene activation, and growth factor independent proliferation." "Therefore, cancer cells likely require a block in apoptosis in order to survive. Overexpression of the antiapoptotic protein BCL-2 provides a block in apoptosis that is frequently observed in cancer cells. We have developed methods for the detection and ana-lysis of BCL-2 dependence and here apply them to acute lymphoblastic leukemia (ALL). BH3 profiling, a...
Source: Cancer Weekly (2008-04-08)
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