Cancer Weekly
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Angiogenesis
Studies from Vanderbilt University, Medical Department yield new information about angiogenesis
April 8th, 2008
According to recent research published in the journal Blood, "To define the role of the alpha 2 beta 1 integrin in pathologic angiogenesis, we investigated tumor-associated growth and angiogenesis in wild-type and alpha 2-null mice. Our findings reveal that the alpha 2 beta 1 integrin plays an important role in angiogenesis via regulation of VEGFR1 expression." "When challenged with B16F10 melanoma cells, mice lacking alpha 2 beta 1 integrin expression exhibit increased tumor angiogenesis associated with up-regulated VEGFR1 expression. In contrast, there was no alpha 2 beta 1 integrin-dependent difference in the angiogenic response to Lewis lung carcinoma (LLC)...
Source: Cancer Weekly (2008-04-08)
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