Cancer Weekly
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Apoptosis
New apoptosis study results reported from University of Versailles
April 8th, 2008
"The accumulation of Ca2+ in the mitochondrial matrix can stimulate oxidative phosphorylation, but can also, at high Ca2+ concentrations, transmit and amplify an apoptotic signal. Here, we characterized the capacity of physiological stimuli (for example, histamine and inositol-1,4,5-triphosphate) and inducers of endoplasmic reticulum (ER) stress (for example, A23187, thapsigargin and tunicamycin) to release Ca2+ from ER stores, induce mitochondrial Ca2+ accumulation, and trigger cell death in human cervix and colon carcinoma cell lines," scientists in Versailles, France report. "Sustained Ca2+ accumulation in the mitochondrial matrix induced by ER stress triggered signs...
Source: Cancer Weekly (2008-04-08)
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