Human Herpesvirus 8
Scientists at Dana-Farber Cancer Institute, Department of Medical Oncology publish new data on human herpesvirus 8
Published in Cancer Weekly, April 8th, 2008
Researchers detail in 'BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2,' new data in human herpesvirus 8. "The Epstein-Barr and Kaposi's sarcoma gamma-herpesviruses (KSHVs) are associated with certain cancers, and encode B-cell leukemia/lymphoma 2 (BCL-2) homologs, BHRF-1 and KSHV BCL-2, respectively. Little is known, however, about the molecular interactions allowing viral BCL-2 homologs to mediate their anti-apoptotic function," scientists in the United States report.
"Cellular anti-apoptotic proteins, such as BCL-2 and MCL-1, prevent death via selective interactions with pro-death BH3-only proteins. To investigate whether BHRF-1 and...
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Source: Cancer Weekly (2008-04-08)
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