Cancer Weekly
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Bladder Cancer
Reports outline bladder cancer research from O.J.C. Hellwinkel and colleagues
April 8th, 2008
"To evaluate CpG island methylation patterns of cancer-associated genes for their applicability as molecular biomarkers for the detection of superficial bladder cancer and for the discrimination of invasive from noninvasive tumours. We analysed the methylation status of CpG islands in the promoter region of the cancer-associated genes GSTP1, DAPK, MDR1, TPEF, PAX6, and TSLC1 in primary papillary bladder cancer specimens from 39 patients (pT1 10, pTis one, pTa 20, pT2 five)," investigators in Hamburg, Germany report. "Tumour-adjacent normal mucosa served as the control. The DNAs were bisulphite-treated and submitted to methylation-specific real-time polymerase chain...
Source: Cancer Weekly (2008-04-08)
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