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Cancer Gene Therapy
New cancer gene therapy research from K.A. Bickenbach et al outlined
April 8th, 2008
According to a study from the United States, "We report the anticarcinogenic, anti-aging polyphenol resveratrol activates the radio- and chemo-inducible cancer gene therapy vector Ad. Egr.TNF, a replication-deficient adenovirus that expresses human tumor necrosis factor a (TNF-alpha) under control of the Egr-1 promoter." "Like ionizing radiation or chemotherapeutic agents previously shown to activate Ad. Egr. TNF, resveratrol also induces Egr-1 expression from its chromosomal locus with a possible role for Egr-1 promoter CC(A+T) richGG sequences in the expression of TNF-alpha. Resveratrol induction of TNF-alpha in Ad. Egr. TNF-infected tumor xenografts demonstrated...
Source: Cancer Weekly (2008-04-08)
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