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Cancer Gene Therapy
Findings from Sheba Medical Center, Department of Gynecology provide new insights into cancer gene therapy
April 15th, 2008
Research findings, 'Hypermethylation of CpG island loci of multiple tumor suppressor genes in retinoblastoma,' are discussed in a new report. According to recent research from Tel Hashomer, Israel, "Epigenetic silencing of tumor suppressor genes by methylation of discrete regions of the CpG islands is a major mechanism underlying tumorigenesis. Methylation of at least three of five specific genes may represent a distinct trait, termed the CpG island methylator phenotype (CIMP)." "Positive CIMP is associated with BRAF mutations. The present study sought to investigate the presence of BRAF mutations in human retinoblastoma and the role of epigenetic silencing of multiple...
Source: Cancer Weekly (2008-04-15)
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