Enzyme Research

Studies from Harvard University, Medical Department add new findings in the area of enzyme research

Published in Cancer Weekly, April 15th, 2008

"Many tumour cells have elevated rates of glucose uptake but reduced rates of oxidative phosphorylation. This persistence of high lactate production by tumours in the presence of oxygen, known as aerobic glycolysis, was first noted by Otto Warburg more than 75 yr ago(1)," scientists in the United States report.

"How tumour cells establish this altered metabolic phenotype and whether it is essential for tumorigenesis is as yet unknown. Here we show that a single switch in a splice isoform of the glycolytic enzyme pyruvate kinase is necessary for the shift in cellular metabolism to aerobic glycolysis and that this promotes tumorigenesis. Tumour cells have been shown to...

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Source: Cancer Weekly (2008-04-15)

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