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Cancer Gene Therapy
Investigators at University of Helsinki, Department of Medical Genetics have published new data on cancer gene therapy
April 15th, 2008
A report, 'Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells,' is newly published data in DNA Repair. "We previously identified a novel genomic instability phenotype of multiple reciprocal chromosomal translocations in a MLH1-defective, microsatellite unstable (MSI) colon cancer cell line (HCA7) and, further, showed that it was unlikely to be directly caused by the mismatch repair (MMR) defect in this cell line. To gain insight into the molecular basis to this novel translocation phenotype, we examined coding and splice-site nucleotide repeat tracts in DNA repair genes for mutations by direct...
Source: Cancer Weekly (2008-04-15)
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