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Gene Therapy
Researchers from University of Nice-Sophia Antipolis detail findings in gene therapy
April 15th, 2008
A new study, 'Plasmidic CpG sequences induce tumor microenvironment modifications in a rat liver metastasis model,' is now available. According to a study from France, "Bacterial DNA contains unmethylated cytosine-phosphate-guanine (CpG) motifs which are recognized by mammalian immune cells as a danger signal indicating an infection. These immunostimulatory properties led to the use of oligodeoxynucleotides bearing CpG motifs (CpG-ODN) for cancer treatment in preclinical and clinical studies." "Although naked DNA administration presently represents 18% of the gene therapy clinical trials worldwide, most of the work regarding the effects of unmethylated CpG sequences was...
Source: Cancer Weekly (2008-04-15)
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