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Neuroblastoma Gene Therapy
New findings from Emory University, Department of Pediatrics in the area of neuroblastoma gene therapy published
April 15th, 2008
New research, 'Tissue factor/FVIIa activates Bcl-2 and prevents doxorubicin-induced apoptosis in neuroblastoma cells,' is the subject of a report. "Tissue factor (TF) is a transmembrane protein that acts as a receptor for activated coagulation factor VII (FVIIa), initiating the coagulation cascade. Recent studies demonstrate that expression of tumor-derived TF also mediates intracellular signaling relevant to tumor growth and apoptosis," scientists in the United States report. "Our present study investigates the possible mechanism by which the interaction between TF and FVIIa regulates chemotherapy resistance in neuroblastoma cell lines. Gene and siRNA transfection was...
Source: Cancer Weekly (2008-04-15)
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