Cancer Weekly
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Vaccines
Study data from University of Southampton, Cancer Sciences Division update knowledge of vaccines
April 15th, 2008
Fresh data on vaccines are presented in the report 'Tapasin shapes immunodominance hierarchies according to the kinetic stability of peptide - MHC class I complexes.' "Peptide loading of MHC class I molecules involves multiple cofactors including tapasin. We showed previously in vitro that tapasin edits the peptide repertoire by favoring the binding of peptides with slow dissociation rates," researchers in Southampton, the United Kingdom report. "Here, using tapasin-deficient mice and a DNA vaccine that primes directly, we confirm that tapasin establishes hierarchical responses in vivo according to peptide-MHC stability. In contrast, this hierarchy is lost when the...
Source: Cancer Weekly (2008-04-15)
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