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Pusan National University, Department of Physiology reports research in cancer

Published in Cancer Weekly, April 15th, 2008

A new study, 'Differential effect of NF-kappaB activity on beta-catenin/Tcf pathway in various cancer cells,' is now available. "beta-Catenin/Tcf and NF-kappaB pathways play an important role in biological functions. We determined the underlying mechanisms of differential interaction between two pathways in various human cancer cell lines," scientists in Korea report.

"NF-kappaB positively regulated beta-catenin/Tcf pathways in human glioblastoma, whereas it has an opposite effect on beta-catenin/Tcf pathways in colon, liver, and breast cancer cells. Expression of lucine zipper tumor suppressor 2 (lzts2) was positively regulated by NF-kappaB activity in colon, liver,...

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