Cancer Weekly
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Angiogenesis
Recent findings in angiogenesis described by D. Loven and colleagues
April 15th, 2008
"Metronomic low-dose chemotherapy regimen was found to have an antiangiogenic effect in tumors. However, its effect on levels of circulating pro-angiogenic and anti-angiogenic factors is not fully explored," scientists in Afula, Israel report. "The levels of both VEGF and PDGF-BB were measured in three time points, in the serum of 32 rectal carcinoma patients receiving daily reduced-dose/continuous capecitabine in combination with preoperative pelvic irradiation. We found a significant decrease in VEGF and PDGF-BB serum levels during the combination treatment (p <0.0001), followed by an increase in the successive rest-period (p <0.0001). In addition, substantial...
Source: Cancer Weekly (2008-04-15)
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