Cancer Weekly
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Bladder Cancer
Studies from National Cheng-Kung University, Medical Department in the area of bladder cancer described
April 15th, 2008
"Oncolytic adenoviruses are attractive therapeutics for cancer because they selectively replicate in tumors. However, targeting tumor metastasis remains a major challenge for current virotherapy for cancer," scientists writing in the journal Clinical Cancer Research report. "Oct-3/4 is specifically expressed in embryonic stem cells and tumor cells. Oct-3/4 highly expressed in cancer cells may be a potential target for cancer therapy. We developed an E1B-55 kDa-deleted adenovirus, designated Ad.9OC, driven by nine copies of Oct-3/4 response element for treating Oct-3/4-expressing metastatic bladder cancer. We examined the expression of Oct-3/4 in human bladder...
Source: Cancer Weekly (2008-04-15)
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