Cancer Weekly
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Angiogenesis
Research from University of Rennes has provided new data on angiogenesis
April 22nd, 2008
Researchers in Rennes, France conducted a study "To study the implication of prokineticin 1 (PK1/EG-VEGF) and prokineticin 2 (PK2/Bv8) in hepatocellular carcinoma angiogenesis. The gene induction of PK1/EG-VEGF and PK2/Bv8 was investigated in 10 normal, 28 fibrotic and 28 tumoral livers by using real time PCR." "Their expression was compared to the expression of VEGF (an angiogenesis marker), vWF (an enclothelial cell marker) and to CD68 (a monocyte/macrophage marker). Furthermore, the mRNA levels of PK1/EG-VEGF, PK2/Bv8, prokineticin receptor 1 and 2 were evaluated by real time PCR in isolated liver cell populations. Finally, PK2/Bv8 protein was detected in normal...
Source: Cancer Weekly (2008-04-22)
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