Cancer Weekly
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Angiogenesis
Research on angiogenesis detailed by scientists at Harvard University, Medical Department
April 22nd, 2008
"Angiogenesis and inflammation are central processes through which the tumor microenvironment influences tumor growth. We have demonstrated recently that peroxisome proliferator-activated receptor (PPAR)a deficiency in the host leads to overt inflammation that suppresses angiogenesis via excess production of thrombospondin (TSP)-1 and prevents tumor growth," scientists writing in the journal Proceedings of the National Academy of Sciences of the United States of America report. "Hence, we speculated that pharmacologic activation of PPAR alpha would promote tumor growth. Surprisingly, the PPAR alpha agonist fenofibrate potently suppressed primary tumor growth in...
Source: Cancer Weekly (2008-04-22)
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