Cancer Weekly
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Apoptosis
New apoptosis research reported from University of Shizuoka
April 22nd, 2008
According to a study from Shizuoka, Japan, "Apoptosis is an important cell death system that deletes damaged and mutated cells to prevent cancer. We have previously reported that a certain dose of UVB irradiation inhibited the apoptosis induced by serum starvation and cell detachment, leading to cell transformation." "This antiapoptotic effect was partially inhibited by pbosphatidylinositol 3-kinase (PI3-kinase) inhibitors. UVB irradiation is known to cause the phosphorylation of Akt via the activation of PI3-kinase; however, the Akt isoform-specific relationship has not yet been clarified. Notably, the role in antiapoptotic effect of UVB has yet to be elucidated. In...
Source: Cancer Weekly (2008-04-22)
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