Cancer Weekly
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Apoptosis
Researchers at South China Normal University have published new data on apoptosis
April 22nd, 2008
"Photodynamic therapy (PDT) employing photosensiter N-aspartyl chlorin e6 (NPe6) can induce lysosome disruption and initiate the intrinsic apoptotic pathway. Yet the precise signal transduction pathway remains poorly understood," investigators in Guangzhou, People's Republic of China report. "In this study, we have investigated the molecular mechanism in NPe6-PDT-induced apoptosis in human lung adenocarcinoma cells (ASTC-a-1). A recombinant fluorescence resonance energy transfer (FRET) Bid probe was utilized to determine the kinetics of Bid cleavage. The results show that cleavage of the Bid-FRET probe occurred 150 +/- 5 min after NPe6-PDT treatment, and this process...
Source: Cancer Weekly (2008-04-22)
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