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Cancer Gene Therapy
Research reports from Shandong University, Medical Department provide new insights into cancer gene therapy
April 22nd, 2008
According to a study from Jinan, People's Republic of China, "It has been reported that over-expression of vascular endothelial growth factor-C (VEGF-C) in tumors leads to increased lymphangiogenesis and resistance to chemotherapy. Therefore, we hypothesized that VEGF-C would be a good molecular target for cancer gene therapy." "In this study, we silenced the expression of VEGF-C with the highly specific post-transcriptional suppression of RNA interference (RNAi) in human breast cancer MCF-7 cell line. The expression of VEGF-C was examined by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA), and the effect of plasmid...
Source: Cancer Weekly (2008-04-22)
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