Cancer Vaccines

Investigators at University of British Columbia have published new data on cancer vaccines

Published in Cancer Weekly, April 22nd, 2008

According to recent research from Vancouver, Canada, "Tpn is a member of the MHC class I loading complex and functions to bridge the TAP peptide transporter to MHC class I molecules. Metastatic human carcinomas often express low levels of the antigen-processing components Tapasin and TAP and display few functional surface MHC class I molecules."

"As a result, carcinomas are unrecognizable by effector CTLs. The aim of this study is to examine if Tapasin (Tpn) plays a critical role in the escape of tumors from immunologic recognition. To test our hypothesis, a nonreplicating adenovirus vector encoding human Tpn (AdhTpn) was constructed to restore Tpn expression in vitro...

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Source: Cancer Weekly (2008-04-22)

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