Cancer Weekly
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Cancer Vaccines
Investigators at University of British Columbia have published new data on cancer vaccines
April 22nd, 2008
According to recent research from Vancouver, Canada, "Tpn is a member of the MHC class I loading complex and functions to bridge the TAP peptide transporter to MHC class I molecules. Metastatic human carcinomas often express low levels of the antigen-processing components Tapasin and TAP and display few functional surface MHC class I molecules." "As a result, carcinomas are unrecognizable by effector CTLs. The aim of this study is to examine if Tapasin (Tpn) plays a critical role in the escape of tumors from immunologic recognition. To test our hypothesis, a nonreplicating adenovirus vector encoding human Tpn (AdhTpn) was constructed to restore Tpn expression in vitro...
Source: Cancer Weekly (2008-04-22)
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