Cancer Weekly
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Breast Cancer
Data from University of Gottingen provide new insights into breast cancer
April 22nd, 2008
According to recent research published in the journal Gynecological Endocrinology, "The majority of human endometrial, ovarian and breast cancers express receptors for gonadotropin-releasing hormone (GnRH). Their proliferation is time- and dose-dependently reduced by GnRH and its agonistic analogs." "GnRH agonists; inhibit the mitogenic signal transduction of growth factor receptors via activation of a phosphotyrosine phosphatase, resulting in downregulation of cancer cell proliferation. Induction of apoptosis is not involved. Recently we showed that the GnRH agonist triptorelin induces activation of nuclear factor-kappa B (NF kappa B) and thus reduces the...
Source: Cancer Weekly (2008-04-22)
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