Gene Therapy
Recent siRNA Research Publications Support Silence Therapeutics Combined Development Approach
Published in Cancer Weekly, April 22nd, 2008
Silence Therapeutics plc (AIM:SLN) Europe's leading RNAi-focused biotechnology company, today comments on two recent journal articles: Nature(1) "Sequence-and target-independent angiogenesis suppression by siRNA via TLR3" Mark E. Kleinman, et. al., and Molecules and Cells(2) "Immune Activation by siRNA/Liposome Complexes in Mice is Sequence-Independent: Lack of a Role for Toll-like Receptor 3," Kim et. al. In these two publications, researchers questioned current thinking on the mode of action of siRNA therapeutics suggesting that they work by mechanisms other than via specific gene silencing.
Data published in the Nature article (Kleinman et. al.) have been interpreted...
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Source: Cancer Weekly (2008-04-22)
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