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Cancer Gene Therapy
Study findings from C.M. Liu et al provide new insights into cancer gene therapy
April 29th, 2008
According to recent research from Beijing, People's Republic of China, "Myostatin is a negative regulator of myogenesis, and inactivation of myostatin leads to muscle growth. Here we have used modified RNA oligonucleotides targeting the myostatin mRNA and examined the therapeutic potential in normal and cancer cachexia mouse models." "We found that the RNA oligonucleotides could suppress the myostatin expression in vivo, leading to the increase in muscle growth both in normal and cachectic mice. We also established that the effect of myostatin inhibition caused by the RNA oligonucleotides may be through the MyoD pathway, as evidenced by a significant upregulation of...
Source: Cancer Weekly (2008-04-29)
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