Cancer Weekly
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Gene Therapy
Scientists at University of Illinois release new data on gene therapy
April 29th, 2008
According to a study from the United States, "The lack of safe and effective delivery vectors continues to be a critical limitation facing human gene therapy. Viruses offer excellent efficiency but can be difficult and expensive to produce and purify." "For example, the production and efficiency of murine leukemia virus (MLV) are limited by its inherent instability; the half-life of infectivity is 5 - 8 hours at 37 degrees C. In order to generate a stable MLV, we randomly mutated the virus genome and selected for infectivity after prolonged incubation at 37 degrees C. After seven rounds of incubation and infection, we isolated a pool of MLV variants with double the...
Source: Cancer Weekly (2008-04-29)
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