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Cancer Gene Therapy
Studies from Jinan University, Medical College provide new data on cancer gene therapy
April 29th, 2008
Research findings, 'VEGF-specific siRNAs modified with 2'-deoxy effectively suppress VEGF expression and inhibit growth of nasopharyngeal carcinoma xenograft in a mouse model,' are discussed in a new report. "Vascular endothelial growth factor (VEGF) is up-regulated in the vast majority of human tumors. The up-regulation of VEGF not only plays important roles in tumor angiogenesis, but also provides a target for tumor treatment with small interfering RNA (siRNA) that targets VEGF; however, it is unclear whether a quite high up-regulation of VEGF will affect the efficiency of RNA interference strategies targeting VEGF," scientists in Shenzhen, People's Republic of China report....
Source: Cancer Weekly (2008-04-29)
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