Cancer Weekly
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Angiogenesis
Researchers at University of Montreal publish new data on angiogenesis
April 29th, 2008
"The integrin alpha(v)beta(3) is involved in multiple aspects of malignant cancer, including tumor angiogenesis and metastasis, which makes the receptor a key target for the development of anti-cancer therapies. We report here on the production, the characterization and the in vivo anti-angiogenic and anti-metastatic properties of a novel alpha(v)beta(3)-binding disintegrin, DisBa-01, isolated from a cDNA library made with RNAs from the venom gland of Bothrops alternatus," scientists writing in the journal Clinical & Experimental Metastasis report. "The 11,637 Da-recombinant monomeric form of DisBa-01 displayed an RGD motif and interacted with purified...
Source: Cancer Weekly (2008-04-29)
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