Cancer Weekly
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Apoptosis
Studies from Y.C. Chang and colleagues provide new data on apoptosis
April 29th, 2008
According to recent research published in the Journal of Cellular Biochemistry, "Tumor suppressor p53 is an essential regulator in mammalian cellular responses to DNA damage including cell cycle arrest and apoptosis. Ourstudy with Chinese hamster ovary CHO-K1 cells indicates that when p53 expression and its transactivation capacity was inhibited by siRNA, UVC-induced G2/M arrest or apoptosis were unaffected as revealed by flow cyotmetric analyses and other measurements." "However, inhibition of p53 rendered the cells slower to repair UV-induced damages upon a plasmid as shown in host cell reactivation assay. Furthermore, the nuclear extract (NE) of p53...
Source: Cancer Weekly (2008-04-29)
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