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Cancer Gene Therapy
Data on cancer gene therapy discussed by researchers at University of Oxford
April 29th, 2008
"Adenovirus gene therapy for intraperitoneal (IP) cancer is limited in clinical trials by inefficient tumor cell transduction and development of peritoneal adhesions. We have shown previously that normal virus tropism can be ablated by physically shielding the virus surface with reactive hydrophilic polymers and that linkage of novel ligands enables virus '' retargeting '' through chosen receptors," scientists writing in the journal Molecular Therapy report. "To achieve tumor-selective infection, polymer-coated virus was retargeted using murine epidermal growth factor (mEGF). The resulting mEGF-polymer coated adenovirus lost its normal broad tropism and...
Source: Cancer Weekly (2008-04-29)
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