Cancer Weekly
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Cancer Gene Therapy
New cancer gene therapy study findings have been reported by researchers at INSERM
April 29th, 2008
"Currently, gemcitabine is approved as the first-line therapy for patients with locally advanced or metastatic pancreatic cancer. Unfortunately, because of pre-existing or acquired chemoresistance of most of the tumor cells, gemcitabine has failed to significantly improve the outcome for pancreatic carcinoma patients," investigators in Strasbourg, France report. "The present study explored the possibility of sensitizing pancreatic cancer to gemcitabine chemotherapy by combining the chemotherapy with the proapoptotic genes Bax and TNF-related apoptosis-inducing ligand (TRAIL). We designed two tetracycline-inducible recombinant adenoviruses using the human telomerase...
Source: Cancer Weekly (2008-04-29)
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