Life Sciences
Study findings from M. Adam et al broaden understanding of life sciences
Published in Cancer Weekly, April 29th, 2008
Current study results from the report, 'Tirapazamine plus cisplatin and irradiation in a mouse model: improved tumor control at the cost of increased toxicity,' have been published. According to recent research from Germany, "Tirapazamine (TPZ) reportedly enhances the tumor cell killing effect of cisplatin up to fivefold and it is an attractive drug for combination with radiotherapy. We evaluated the toxicity of a fractionated combined treatment."
"Murine RIF-1 fibrosarcomas growing on the right hind foot of C3-H mice were used. Within 2 weeks, animals were treated with six i.p. injections of TPZ (43.2-172.8 mg/kg total), and/or cisplatin (24 mg/kg total) and ten...
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Source: Cancer Weekly (2008-04-29)
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