Cancer Weekly
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Leukemia Gene Therapy
Research from Erasmus University reveals new findings on leukemia gene therapy
May 6th, 2008
According to recent research from Netherlands, "Recombinant retroviruses are one of the most commonly used gene transfer vehicles for therapeutic gene delivery. The stability of viral vectors upon long-term storage, anticipated to be short lived, is expected to impact timeline and financial course of clinical immunogene therapy." "However, to date little is known about vector stability. Therefore, we analyzed the stability of retroviral vectors produced in culture supernatants (RTVsup) for ex vivo gene therapy upon long-term storage. We have generated RTVsups derived from two packaging cell lines, PG13 and Phoenix(Ampho). Both lines produced murine leukemia...
Source: Cancer Weekly (2008-05-06)
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