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Cancer Weekly

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Cancer Gene Therapy



Researchers from University of Texas, M. D. Anderson Cancer Center discuss findings in cancer gene therapy



May 6th, 2008

Fresh data on cancer gene therapy are presented in the report 'Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation.' "Imprinted tumor suppressor genes may be particularly important in the pathogenesis of ovarian cancer. Two imprinted genes, paternally expressed 3 (PEG3) and aplasia Ras homologue member I (ARHI), are the most frequently down-regulated in ovarian cancers on gene expression arrays," investigators in the United States report.

"PEG3 and ARHI expression levels were evaluated with real-time reverse-transcriptase polymerase chain reaction (PCR)...


Source: Cancer Weekly (2008-05-06)

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